Firefighters and US troops joined neighbours to dig through the debris and under toppled blast barriers to pull victims from the rubble. The blasts appear to be the second attack against a hotel housing international journalists. At first the target appeared to be an Interior Ministry building nearby where US troops found about 170 detainees, some of whom appeared to be tortured. "What we have here appears to be two suicide car bombs (that) attempted to breach the security wall in the vicinity of the hotel complex and I think the target was the Hamra Hotel," US Brig Gen Karl Horst told reporters at the scene. The blasts - less than a minute apart - reverberated throughout the city centre, sending a mushroom cloud hundreds of feet into the air, followed by sporadic small arms fire. The suicide attackers targeted the Sheik Murad mosque and the Khaniqin Grand Mosque - both homes to Shiite Muslims - in Khanaqin, 140 kilometres northeast of Baghdad, as dozens of people were attending prayers, police said. The police command said 65 people were killed and 75 injured in the largely Kurdish town. The blast near the Hamra hotel in Baghdad knocked down the blast walls protecting the hotel and blew out windows, but did no structural damage.

In the second case, a 14-year-old apparently fell from the ninth floor of his apartment building in February 2005.In a statement issued last night, the EMEA said it had asked Roche to "provide a cumulative safety review of all available data on serious psychiatric disorders, including all case reports with a fatal outcome where Tamiflu was involved".. Suicide bombers killed 65 worshippers at two mosques in eastern Iraq today while in Baghdad two car bombs destroyed the blast wall protecting a hotel housing foreign journalists and killed eight Iraqis. Under the yellow card system doctors record symptoms that could be linked with a drug. The reports are intended to provide early warning of possible problems.In the UK, the side effects listed for Tamiflu include nausea, fatigue, insomnia, dizziness, rash and - rarely - hepatitis and Stevens-Johnson syndrome, a life-threatening condition in which the skin blisters and sloughs off.The two Japanese boys who died in separate accidents were reported to have exhibited abnormal behaviour after taking the drug. A high school student of 17, who was at home alone, ran out of his house and jumped over a railing into the path of a lorry in February 2004, shortly after taking the medicine. One case was of agitation and two were of "confusional state".

The drug is routinely used by all sectors of the population during the winter flu season to shorten the duration of the illness, reduce complications and slow its spread. The Japanese health ministry issued a warning in June last year about psychological and neurological disorders linked with Tamiflu.The European Medicines Evaluation Agency (EMEA), which licenses drugs in the EU, said that it had asked Roche to follow closely reports of psychological disorders, delusional states and abnormal behaviour linked with the drug.In the UK, Tamiflu has been little used since its launch in 2003 and there have been only 41 "yellow card" reports linked with it of adverse reactions, involving 161 separate side-effects. Three million courses have been delivered and the remainder is due by September next year.Japan is the only country with extensive experience of Tamiflu. At least 50 countries including the US, UK and Japan have placed orders worth $1.4bn (£810m) to prepare for a flu pandemic experts say is inevitable.The British Government has ordered 14.6 million courses of Tamiflu at a cost of £200m. One question they will have to address is how to distinguish the effects of the drug from the effects of the flu.In a separate summary posted on the FDA web site, Roche, the manufacturer of Tamiflu, said: "There is no increase in deaths and neuropsychiatric events in patients on Tamiflu versus influenza patients in general." Officials from the FDA and the Swiss drugs giant will present information about the cases to an FDA advisory panel today.Demand for Tamiflu has soared as avian flu, which has killed at least 64 people in the Far East, has spread to birds and poultry Europe. All had taken Tamiflu."Deaths from influenza are uncommon among both children with and without high-risk conditions, but do occur," the FDA report said. "Attribution of causality for the reports of sudden death and cardio-pulmonary arrest are extremely difficult to interpret because there is limited information leading up to the event." It added that it was "concerning" that 32 psychiatric events, such as hallucinations and abnormal behaviour, had been reported in children who took Tamiflu.A panel of the FDA is examining reports of adverse reactions to Tamiflu as part of a wider review of how medicines work in children.